Long COVID, characterized by persistent symptoms after the acute phase of SARS-CoV-2 infection, has become a significant concern. Some individuals can endure persistent, debilitating symptoms for many months after an initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the factors underpinning these health issues are poorly understood.
Comparing the blood serum profiles of patients with confirmed SARS-CoV-2 infection with that of uninfected controls, Cervia-Hasler et al. found that patients experiencing Long COVID exhibited changes to blood serum proteins, indicating activation of the immune system’s complement cascade, altered coagulation, and tissue injury.
Complement dysregulation is a phenomenon where the immune system's complement proteins are not tightly controlled, leading to excessive or inadequate activation. The authors observed persistent complement activation in Long COVID patients, suggesting a prolonged state of immune system imbalance. This dysregulation was further implicated in the observed thromboinflammation, a process involving both blood clotting and inflammation.
Thromboinflammation has been increasingly recognized as a contributor to the complications observed in severe COVID-19 cases. This study extends the understanding of thromboinflammation into the context of Long COVID, emphasizing its persistence even after the acute phase of infection. The authors underscore the importance of monitoring and addressing complement dysregulation to mitigate the risk of thromboinflammation in Long COVID patients.
Cited product
| Cat-No. | Item | Size | Price (CHF) |
|---|---|---|---|
| LU001000 | QuickBlue Protein Stain, 1 Liter, 40 mini-gels | 1 l | 155.00 |