What are species-matched antibodies?
VivopureX™ antibodies are recombinant mouse antibodies ideal for in vivo research in mouse models. The collection consists of popular antibody clones, many originally obtained from rats or hamsters, which Absolute Antibody has engineered into mouse anti-mouse recombinant versions to improve research results.
Benefits of species-matched antibodies
Our VivopureX™ antibodies offer many advantages compared to the original antibody format, as illustrated by our data below. In this example, our recombinant mouse PD-1 antibody based on the widely used clone RMP1-14 reduced tumor size in a mouse model more effectively than the original rat version.
- Reduced immunogenicity: no neutralizing antibodies are induced in the host organism, meaning the antibody works for longer and cohorts respond more consistently
- Tailored effector function: the antibody format has been engineered to suit its most popular applications
- Increased potency: less antibody is required to achieve the same response in mouse models
- Batch-to-batch reproducibility: recombinant production ensures the highest possible reproducibility, while guaranteeing high purity and low endotoxin levels
Comparison of the effectiveness of unmatched and species-matched antibodies in inhibiting in vivo tumor growth
The graph on the right shows tumor sizes in mice treated with either a conventional rat anti PD-1 antibody (red) or a species-matched VivopureX (pink). After 20 days, tumors in mice treated with the conventional rat antibody start to grow again because the immune system recognizes and eliminates the rat anti PD-1 antibody. The species-matched antibody remains unaffected. Use of species-matched antibodies thus allows for longer in vivo studies and more relevant data.
Immunotherapy research antibodies
Absolute Antibody offers recombinant engineered antibodies against clinically relevant immune checkpoints, including mouse homologues of current therapeutic targets. These are proven antibody clones, updated via antibody engineering for improved performance in vivo.
- Reduce immunogenicity by matching the antibody species to your host organism
- Tailor effector function by choosing from a wide range of isotypes and subtypes
- Combine two antibody clones into a custom bispecific reagent
Selected VivopureX antibodies
| Cat-No. | Item | Size | Price (CHF) |
|---|---|---|---|
| Ab00813-2.3 | Anti PD-1 [RMP1-14], IgG2a, Fc Silent™ | 200 ug | 611.00 |
| Ab00110-1.1 | Anti CD134 [OX86], IgG1 | 200 ug | 611.00 |
| Ab01419-3.0 | Anti PD-L1 [10F.9G2], IgG2b | 200 ug | 611.00 |
| Ab01018-2.0 | Anti CTLA-4 [9D9], IgG2a | 200 ug | 611.00 |
| Ab01107-2.0 | Anti CD25 [PC-61.5.3], IgG2a | 200 ug | 611.00 |
| Ab01490-2.3 | Anti IL-10R [1B1.3a], IgG2a, Fc Silent™ | 200 ug | 611.00 |
| Ab00205-2.0 | Anti CD4 epitope A [YTS 177.9], IgG2a | 200 ug | 611.00 |
| Ab01088-2.3 | Anti Galectin 9 [RG9-35], IgG2a, Fc Silent™ | 200 ug | 611.00 |
| Ab01089-2.0 | Anti CD153 [RM153], IgG2a | 200 ug | 611.00 |