LubioScience provides high-quality, affordable fetal bovine serum (FBS) and various other animal sera from our supplier Biowest.
Your benefits at a glance:
- FBS with European origin is available.
- Biowest sera deliver consistent cell growth over time and passages.
- Premium FBS with assured lot-to-lot consistency available.
- Various options for serum treatment/processing.
- Traceability: ISO 9001:2015 and ISO 13485:2016 certification.
- Each batch of sterile serum is controlled internally, from the importation of the raw serum, to final filtration and labelling.
- Transparency: Each product is delivered with different documents: Certificate of analysis, health certificate, EDQM certificate, and certificate of origin.
- Animal welfare: The production process of animal sera complies with Animal Welfare Principles established by The World Organization for Animal Health.
Fetal bovine serum
Fetal Bovine Serum is the liquid part of the blood depleted of the cellular fraction and coagulation factors. It is extracted from clotted fetal bovine blood, collected aseptically, after centrifugation. Sterile FBS is obtained by triple 0.1µm-filtration.
Fetal Bovine Serum contains proteins and growth factors allowing maintenance and proliferation of eukaryotic cells in vitro. It also contains attachment factors that create a “coating” effect on the plastic of the support, thus increasing cell adhesion. It is an essential product in cell culture because of the different components it provides.
All FBS batches are tested for endotoxin and mycoplasma levels, specific viruses (BVD), hemoglobin and total protein rates, and cell culture performance.
We offer FBS sourced in the EU
When researchers choose their serum, an important factor that should be taken into consideration is the source, which also emphasises the traceability of the serum. Biowest's system of vertical integration allows researchers to be certain of the origins and traceability of the FBS. Each manufactured batch is rigorously controlled, from the collection of serum and throughout all stages of its treatment and production through to final packaging on Biowest's premises. The serum is collected or imported and treated in agreement with the European regulations.
We offer FBS that was collected in Europe. European FBS benefits from Welfare Guidelines – for animal treatment on farms, during transportation, and in slaughterhouses – laid out by EU regulations.
Discover FBS from other geographical regions:
| Cat-No. | Item | Size | Price (CHF) |
|---|---|---|---|
| S1300-500 | Fetal Bovine Serum (South Africa Origin) | 500 ml | price on request |
| S1520-500 | Fetal Bovine Serum (USA Origin) | 500 ml | price on request |
| S1560-500 | Fetal Bovine Serum (Chile. USDA approved) | 500 ml | price on request |
| S1580-500 | Fetal Bovine Serum (Uruguay) | 500 ml | price on request |
| S1600-500 | Fetal Bovine Serum (Central America. USDA approved) | 500 ml | price on request |
| S1650-500 | Fetal Bovine Serum (Mexico. USDA approved) | 500 ml | price on request |
| S1810-500 | Fetal Bovine Serum (South America) | 500 ml | price on request |
Want to test a specific lot before purchase? We offer free 50 ml samples! During your tests, the respective lot will be reserved exclusively for you for 4 weeks, so you can purchase the lot afterwards if it worked for you.
Specialized FBS
- Premium: FBS Premium is a selection of the best batches, chosen for their excellent endotoxin, hemoglobin and cell growth values on 4 cell lines, ensuring the success of your cell cultures. By ordering FBS Premium, our customers avoid time-consuming batch testing and batch reservations.
- Embryonic stem cells tested: Pre-screening of the serum is an essential procedure before using it for the culture of mouse Embryonic Stem cells (mES). mES Cell Qualified FBS is manufactured for maximum in vitro growth and maintenance of mES cells in the undifferentiated state.
- Tetracycline free: Tetracyclines are antibiotics usually used during bacterial infection, or to prevent disease development in cattle breeding. The impact of these treatments on FBS is the presence of residual tetracycline derivatives, which can modify biological parameters or Tet-induced gene expression. Biowest Tetracycline-free Serum is tested for the presence of chlorotetracycline, oxytetracycline and tetracycline.
- Ultra-low endotoxin: Endotoxins, i.e. LPS for E. coli, are components of the walls of Gram-negative bacteria. They are released when the bacterial cell dies. Their presence can interfere with biological parameters, like cell activation. Endotoxin-low FBS is used for LPS-sensitive cell lines, such as macrophages and immune cells.
| Cat-No. | Item | Size | Price (CHF) |
|---|---|---|---|
| S140B-500 | Fetal Bovine Serum (EU Origin). Premium | 500 ml | price on request |
| S181B-500 | Fetal Bovine Serum (South America). Premium | 500 ml | price on request |
| S181S-500 | Fetal Bovine Serum (South America). Embryonic Stem Cells tested | 500 ml | price on request |
| S181T-500 | Fetal Bovine Serum (South America). Tetracycline free | 500 ml | price on request |
| S1860-500 | Fetal Bovine Serum (South America). Ultra-low Endotoxin | 500 ml | price on request |
Treated FBS
In order to adapt to your cells, our supplier Biowest offers the possibility to process the sera according to your specifications:
- Charcoal/dextran stripping: Reduces the concentration of steroid hormones in serum such as estradiol, progesterone, cortisol, testosterone, T3 and T4. This serum is useful when endogenous molecules may interfere with experimental work.
- Dialysis: Reduces the concentration of free low molecular weight components such as nucleotides, amino acids, hormones and ions. The dialyzed FBS is recommended for studies with low concentrations of small molecules needed.
- E.V. depletion: FBS contains a large amount of exosomes, which can interfere with the secretion/production of exosomes by the cells of interest. To study exosome functions, Biowest has developed a proprietary ultrafiltration method, which guarantees an extra-vesicle depletion rate of 95% or more.
- Gamma irradiation: Minimizes the risk associated with the use of animal products and offers protection against low levels of microbial contaminants. This treatment has no significant effect on hormones, osmolality, pH, endotoxin levels and the electrophoretic profile, and may reduce hemoglobin levels.
- Heat treatment: Allows the inactivation of the complement acting in the immune system to avoid interference with some experimentation, in particular the tests of immunology. It also allows the inactivation of viruses and the elimination of some bacterial contaminants such as mycoplasma.
- IgG-depletion: Obtained by a proprietary chromatography method, this type of serum is an ideal solution for cell culture and protein purification applications where naturally occurring IgG levels are too high. The IgG level after depletion is <5 µg/ml.
- Iron supplementation: A 1% ferric citrate sterile solution is added to the serum at 0.246% (v/v). Transferrin is normally 20 to 40% bound to iron.
- Lipid depletion: This type of FBS is ideal for research applications where a low concentration of lipids is necessary.
All geographical origins of serum can be treated, please contact us for inquiries.
| Cat-No. | Item | Size | Price (CHF) |
|---|---|---|---|
| S181F-500 | Fetal Bovine Serum (South America). Charcoal Stripped | 500 ml | price on request |
| S181D-500 | Fetal Bovine Serum (South America). Dialysed | 500 ml | price on request |
| S181M-500 | Fetal Bovine Serum (South America). E.V Depleted | 500 ml | price on request |
| S181G-500 | Fetal Bovine Serum (South America). Gamma Irradiated | 500 ml | price on request |
| S181H-500 | Fetal Bovine Serum (South America). Heat Inactivated | 500 ml | price on request |
| S181I-500 | Fetal Bovine Serum (South America). low IgG | 500 ml | price on request |
| S181R-500 | Fetal Bovine Serum (South America). Iron Supplemented | 500 ml | price on request |
| S181L-500 | Fetal Bovine Serum (South America). Lipid Depleted | 500 ml | price on request |
Other animal sera
Discover the complete range of Biowest Animal Sera. All animal sera can be treated upon request. Feel free to contact us.
| Cat-No. | Item | Size | Price (CHF) |
|---|---|---|---|
| S0250-500 | Bovine Serum (France Origin) | 500 ml | price on request |
| S0400-500 | Calf Serum | 500 ml | price on request |
| S0500-500 | Chicken Serum | 500 ml | price on request |
| S2900-100 | Dog (Canine) Serum | 100 ml | price on request |
| S2170-500 | Donkey Serum | 500 ml | price on request |
| S0800-500 | Donor Foal Serum | 500 ml | price on request |
| S0900-500 | Donor Horse Serum | 500 ml | price on request |
| S0960-500 | Fetal Horse Serum | 500 ml | price on request |
| S2000-500 | Goat Serum | 500 ml | price on request |
| S2450-500 | Guinea Pig Serum | 500 ml | price on request |
| S0910-500 | Horse Serum | 500 ml | price on request |
| S2160-500 | Mouse Serum | 500 ml | price on request |
| S0750-500 | New Born Calf Serum | 500 ml | price on request |
| S2400-500 | Pig Serum | 500 ml | price on request |
| S2500-500 | Rabbit Serum (France Origin) | 500 ml | price on request |
| S2150-500 | Rat Serum | 500 ml | price on request |
| S2350-500 | Sheep Serum | 500 ml | price on request |
Serum alternative
FreeAdd 1X is a chemically defined substitute for animal serum. It provides the elements and nutrients necessary for the proliferation and maintenance of cellular characteristics. FreeAdd replaces most supplements such as fetal bovine serum to replicate the normal extracellular environment, making your culture experience predictable, safe and future-proof. Because it is fully defined, there is no need to do batch selection tests. FreeAdd is suitable for use with most animal cell types, cell line or primary, adherent or suspension cells.
| Cat-No. | Item | Size | Price (CHF) |
|---|---|---|---|
| S6010-500 | FreeAdd 1X | 500 ml | 718.00 |