Cell lines are extremely useful tools for the study of protein interactions, gene activation, cell signaling, viral infection, cell-to-cell communication, and other biological processes in the context of an intact cell system rather than cell-free biochemical assays. BPS Bioscience has developed over 250 stable cell lines applicable across a wide range of research areas including immunotherapy, CAR-T cell therapy, cell signaling, metabolism, neuroscience, and much more. We now also feature iPSC-derived cells for drug discovery.
Why chose BPS Bioscience for cell lines?
- Reliable high quality: All cell lines are extensively validated, confirming biological activity when appropriate, tested for viability and mycoplasma before shipping to ensure valid, reproducible results and to minimize the need for end-user optimization and troubleshooting.
- Fast time to results.
- Unique cell line rental service available
- Wide portfolio of over 250 stable cell lines to choose from
- Custom cell line development available for your specific needs. Read more below.
- Detailed protocols and instructions provided.
- ISO 9001:2015-certified Quality Management System
- Produced in-house in San Diego, USA.
View entire cell line selection in shop
Many of our cell lines utilize the firefly luciferase reporter system, in which the firefly luciferase gene is downstream of a response element specific to a particular cell signaling pathway. Upon transcription factor binding to the response element, luciferase RNA is transcribed and translated into a functional luciferase protein. After addition of luciferin, luciferase converts luciferin to oxyluciferin in a reaction that gives off light. This bioluminescent reaction is readily detected, and the amount of light is proportional to the expression of luciferase. Learn more about our luciferase reporter cell lines in this video.
All our cell lines have been extensively validated, confirming biological activity when appropriate, and are provided with detailed protocols that include instructions for general cell culture and maintenance, as well as example experimental setups. Each cell line is tested for viability and mycoplasma before shipping to ensure valid, reproducible results and to minimize the need for end-user optimization and troubleshooting.
Cell signaling encompasses a complex network of communication pathways that enable cells to perceive and respond to external cues, including hormones, growth factors, and environmental stimuli. Understanding cell signaling pathways is essential for unraveling the mechanisms underlying development, homeostasis, immune response, and disease progression. Researchers require techniques such as genetic manipulation, biochemical assays, cell models, and pharmacology to decipher these intricate signaling networks, leading to insights into disease mechanisms. Moreover, advancements in cell signaling research hold promise for the discovery of novel drug targets and the design of more effective treatments for a wide range of medical conditions. BPS Bioscience drives discovery with our rapidly expanding portfolio of reporter cell lines and cell-based assay systems.
Custom Cell Line Development - Get reliable results fast!
BPS Bioscience offers rapid development services for custom cell lines tailored to your specific project.
- Cell lines developed by specialists
- Service includes knockout or overexpressing cell lines, reporter cell lines, co-stimulatory cell lines, CAR-T cells & bioluminescent cells
- Custom-designed to meet your exact specifications
- Choose from >30 parental cell types, including Jurkat, Raji, HEK293, HeLa, and more.
- Choose from >70 available reporter systems such as luciferase, eGFP, and more.
Cell Line Formats
Overexpression
- Positive control for antibody or ligand screening
- Target for CAR-T, BiTE or antibody killing
- Study protein expression effects on cell signaling, proliferation, metabolism, etc.
- Varying expression levels (high, medium, low) to mimic natural variations
Reporter
- High throughput screening tool to identify receptor/pathway inhibitors
- 25+ available promoters and 30+ parental cell lines
- Customize with your gene promoter of interest
- Luciferase, eGFP, or custom reporter systems
Knockout
- CRISPR/Cas9 genome editing ensures stable knockout condition
- KO of immune-mediators such as TCR, B2M and CIITA for universal CAR-T cells
- Study protein KO effects on cell signaling, proliferation, metabolism, activation, etc.
Co-stimulatory
- For use in co-culture with reporter cells
- High throughput inhibitor screening
- TCR activator + customized expression of co-stimulators or checkpoint inhibitors
CAR-T Cells
- Expression of your CAR on immune-derived or other cell lines to model CAR-T function in co-culture studies
- Cell lines or primary CD4+/CD8+ T cells
Bioluminescent
- Constitutive expression of luciferase or eGFP for use in cell line-derived xenograft models or other cell tracking experiments
- Clonally selected for uniformity, providing consistent results
- Can be engineered for protein overexpression or KO.