ACROBiosystems is a leading manufacturer of recombinant proteins and other reagents to support the development of target therapeutics, vaccines, and diagnostics. The company employs an application-oriented development strategy, with a particular focus on product design, quality control and solution-based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process.
ACROBiosystems' catalog includes a comprehensive list of disease-associated biomarkers and drug targets from humans to other common species. All of our products are produced with high quality and batch-to-batch consistency to satisfy the rigorous standards of pharmaceutical research and development.
Facing with the pandemic caused by SARS-CoV-2, ACROBiosystems has been keeping a close eye on the development of the epidemic situation and accelerating the development of SARS-COV-2 antigen proteins, antibodies, kits and other related products to facilitate the development of serologic tests, therapeutic antibodies and vaccines.
ACROBiosystems continue to grow and adapt to bring more value to our clients by providing more technical resources and custom services, promoting training and communication opportunities, initiating collaborations in the bio-industry community, and facilitating transactions in the dynamic global and each niche market.
Products
- Recombinant Proteins
- GMP-grade Cytokines
- Antibodies
- ELISA Kits
- Magnetic Beads
- COVID-19 related Reagents
- and much more!
Discover more here:
Cytokines
Cytokines are a class of small molecule proteins or polypeptides that are stimulated, synthesized or secreted by immune cells (such as monocytes, macrophages, T cells, B cells, NK cells, etc.) and some non-immune cells (endothelial cells, epidermal cells, fibers mother cells, etc.). Cytokines can transmit information between cells. Cytokines have immune regulation and effector functions including the regulation of innate immunity, adaptive immunity, hematopoiesis, repair of damaged tissues, cell growth, and differentiation. Cytokines play an important role in the immune system by regulating the intensity and duration of immune responses.
GMP Grade Cytokines
Immune cell therapy, represented by CAR-T/NK cells has shown significant therapeutic effects in the treatment of various malignant tumors such as leukemia, lymphoma, and multiple myeloma. As more and more immune cell therapies enter the stage of clinical research, quality management systems have attracted more attention from the industry. During the process of immune cell therapy products, cytokines such as IL-15, IL-7, IL-21 are used as a key raw material for T/NK cell activation and amplification. FDA and Chinese Pharmacopoeia have relevant regulations about the use of these key materials. The FDA CMC recommends using FDA-approved or clinical-grade materials. For Chinese Pharmacopoeia regulations, priority should be given to the use of low-risk materials such as GMP grade materials as opposed to non-GMP grade materials. Therefore, safe, effective, and compliant cytokines are crucial for the success of R&D processes and applications of immune cell therapy drugs.
ACROBiosystems is committed to the development of high-quality reagents that are used in the clinical stage of immune cell therapy drugs. Based on the GMP-grade quality management system platform, combined with the production specifications of cell therapy drugs, we have successfully developed a series of high-quality GMP-grade cytokines such as IL-15, IL-7, IL-21. These products are produced with strict quality management and drug-level release testing standards. Our GMP-grade cytokines* can better assist the clinical research of immune cell therapy drugs and accelerate the global regulatory approval of biological products.
* ACROBiosystems GMP grade products are designed for research, manufacturing use, or ex vivo use. CAUTION: Not intended for human in vivo applications.
Anti-idiotypic Antibodies
An idiotope is the unique set of antigenic determinants (epitopes) of the variable portion of an antibody. An anti-idiotypic (Anti-ID) antibody binds to the idiotope of another antibody, usually an antibody drug, which makes it a very powerful tool for antibody drug development, especially for immunogenicity and PK/PD analysis.
To support preclinical/clinical immunogenicity and PK analysis, ACROBiosystems has developed a series of high-affinity anti-idiotypic antibodies. Our pipeline covers five hot targets including adalim*mab, Ritux*mab, Cetux*mab, Trastuz*mab, and Bevaciz*mab. To help the drug development process, we provide assay protocols which can be applied to different application scenarios.
ELISA Kits
Pharmacokinetics (PK) is a branch of science dedicated to the quantitative analysis of absorption, distribution, metabolism and excretion of drug molecules within the body of a living organism. All pre-clinical and clinical studies include the measurement of serum drug concentration, both in animals and in patients, at different points after drug administration. The result is an important indicator of the drug’s pharmacokinetic properties, and is pertinently relevant to dosing recommendations.
The booming market of biologic drugs, driven by a flurry of success with monoclonal antibodies, brings the need for standard high throughput assays to evaluate the content of mAbs in serum samples. Traditionally, the analyses are conducted by indirect ELISA, or with the help of anti-drug antibodies (ADA), each with its own pros and cons. We have developed a series of assays based on the competitive ELISA method. The assay employs a biotinylated mAb against the same target as a tracer to compete with the unlabeled analyte, and uses the interaction between biotin and streptavidin for the eventual readout. This method does not rely on ADAs, and it also alleviates the background issue often occurred with the traditional assay format.
We have launched kits for the studies of CTLA-4, PD-1, and HER-2, respectively, in both humans, and common experimental animals.
Documents
| Filename | Download |
|---|---|
| ACROBiosystems_Solutions_of_Immune_Cell_Therapy_Development.pdf |  |
| ACROBiosystems_CAR-T.pdf | |
| ACROBiosystems_SARS-CoV-2_Products.pdf | |
| ACROBiosystems_Several_types_of_drug_conjugates.pdf | |
