Nordic-MUbio develops and manufactures high quality antibody reagents for use in R&D. All our products are manufactured according to strict ISO 9001 quality guidelines, and their focus is on developing antibodies targeting Cell Adhesion, Nuclear and Cytoskeletal Proteins.
Nordic-MUbio is one of the leading antibody companies developing antibodies for zebrafish research – the company has over 50 antibodies validated for immunofluorescence in zebrafish. In proprietary and partnered development programs, Nordic-MUbio is investigating, testing and validating patented antibodies and antigens for diagnostic applications in the field of lung and other cancers.
SCICONS dsRNA Antibodies
We offer SCICONS mouse anti-dsRNA antibodies, which are the gold standard in double-stranded RNA (dsRNA) detection. The J2, J5, K1 and K2 monoclonal antibody clones are used to detect dsRNA intermediates of a diverse range of viruses, including chikungunya, dengue, hepatitis, rabies, rhinovirus, polio, swine fever and more. The antibodies have been widely applied to study the viral life cycle and anti-viral responses, as well as used as a diagnostic tool to detect whether an unknown pathogen is bacterial or viral. The antibodies are also available packaged in ELISA kits.
The SCICONS antibodies’ high specificity, affinity for a range of synthetic double-stranded polyribonucleotides, and lack of reaction with DNA and single-stranded RNA have been extensively characterized since the antibodies’ development in 1990 (Schönborn et al., 1991).
SCICONS products are widely used for a range of systems and applications, as referenced in more than 300 published studies. For example, review how the SCICONS antibodies helped the fight against SARS-CoV-2 in this article.
The SCICONS antibodies include:
- J2 monoclonal antibody, which is the clone most often used to detect dsRNA intermediates of a wide range of viruses in cells and tissues, for applications including IHC, IF, Western blot, ELISA and electron microscopy.
- Catalog Numbers: 10010200, 10010500
- J5 monoclonal antibody, which is comparable in dsRNA affinity and specificity to the J2 clone, but has a different isotype, making it a flexible tool for simultaneous detection of dsRNA with other markers in IF and more.
- Catalog Numbers: 10040200, 10040500
SCICONS ELISA Kits
Detect the presence of dsRNAs in your samples quickly and effectively using our SCICONS ELISA kits. Built using our highly specific SCICONS antibodies, these sensitive ELISA kits enable the detection of dsRNA molecules (>30-40 bp) in nucleic acid extracts in the presence of 1,000- 10,000-fold excess of other nucleic acids.
The kits include enough reagents for 200 or 500 tests:
- 1 vial of coating antibody
- 1 vial of Poly(I:C) dsRNA as positive control
- 1 vial of dsRNA-specifi c detecting antibody (J2 or K1-based)
- 1 vial of HRP-conjugated F(ab’)2 fragment of goat-anti mouse secondary antibody
- 1 vial of TMB substrate solution
- Clear protocol that walks you through the entire process, from sample preparation to result analysis
